Sarah, a black-footed ferret, is taken by human scientists. Her children, her best friend James (a weasel with serious revenge issues), his crotchety mentor Desmond (a gray squirrel), and a pair of truly birdbrained herons stumble and lurch toward her rescue.
It seems as though the entire natural world stands in their way--and then the supernatural one decides to join in. Across the gulf of miles, James and Sarah find that they share a bond--a dangerous, imperfect thing called love--that cannot be caged.